The ANPC is a world-class facility led by Murdoch University focused on high throughput targeted and exploratory metabolic phenotyping. Located on Level 3 of the Harry Perkins Institute of Medical Research adjacent to Fiona Stanley Hospital, it is the largest dedicated facility for metabolic phenotyping in the world, accommodating more than 30 high-performance mass spectrometers and 10 ultra-high field Nuclear Magnetic Resonance spectrometers. As the Hub of the International Phenome Centre, the ANPC is connected with similar centres around the world, including sites in London, Birmingham, Hong Kong and Singapore. Our infrastructure supports almost every area of bioscience by capitalizing on the latest NMR and MS technologies and advanced data science capabilities. Our approach reaches across traditional research silos and fosters a new, more collaborative approach to research that is critical to solving some of the world’s most challenging problems, including COVID-19.

The Australian National Phenome Centre houses the most concentrated collection of analytical platforms, technology and ancillary equipment used for Phenomics research in the Southern Hemisphere. The ANPC possesses:

• 10 High Field NMR’s, including one 800 MHz NMR, six 600 MHz IVDR Avance III NMR’s and a 600 MHz Neo used for NMR phenomics profiling, a 400 MHz Foodscreener used for provenance, food and nutritional analysis, and a 600 MHz High-Resolution Magic Angle Spinning NMR for solid-state analysis.

• Twelve Bruker Impact II Q-ToF systems that are used for both targeted and untargeted profiling; two Xevo TQ-XS and a TQ-S micro triple quadrupole system used for quantitative/targeted analyses, and a Waters Liquid Chromatography Fractionation system with Acquity QDa detector used for mass-to-charge directed isolation and purification.

• Two Sciex QTRAP 6500+ systems with SelexION+ ion mobility sources for quantitative lipidomics and targeted analyses.
• A Bruker SolariX Magnetic Resonance Mass Spectrometer with dual ESI/MALDI ion source used for spatial metabolomics and rapid screening
• Two Bruker TIMS-TOF Pro ion mobility Q-ToF systems
• Desorption Electrospray Ionisation (DESI) and Rapid Evaporative Ionisation Mass Spectrometry (REIMS) i-knife ion sources are coupled to separate Waters G2-XS QToF platforms enabling advanced surface and tissue-based profiling.

To address the analytical needs of current and future phenomics research we are actively generating new analytical methods and protocols in direct partnership with our technology providers using our NMR and MS platforms. These relationships will allow us to rapidly generate and translate new diagnostic and prognostic tools to the industry and the wider health care network.